{"id":4298,"date":"2020-08-11T09:07:57","date_gmt":"2020-08-11T09:07:57","guid":{"rendered":"https:\/\/demo.theisn.org\/?page_id=4298"},"modified":"2021-01-19T09:50:45","modified_gmt":"2021-01-19T09:50:45","slug":"milestones-in-nephrology","status":"publish","type":"page","link":"https:\/\/www.theisn.org\/about-isn\/history\/milestones-in-nephrology\/","title":{"rendered":"Milestones in Nephrology"},"content":{"rendered":"<p>[vc_row][vc_column][vc_column_text]To mark ISN&#8217;s 60th anniversary, a monthly series, <strong>\u201cMilestones in Nephrology,\u201d<\/strong>\u00a0was developed by the editorial team at <em><a href=\"https:\/\/www.kidney-international.org\/article\/S0085-2538(19)31016-6\/fulltext\" target=\"_blank\" rel=\"noopener noreferrer\">Kidney International<\/a><\/em>\u00a0(KI).<\/p>\n<p>The series highlights 60 historical papers of importance to the nephrology community from the early days of KI<em>. G<\/em>roundbreaking KI papers are discussed by an editor in light of more recent advances in the field.<\/p>\n<p>&nbsp;<\/p>\n<p>[\/vc_column_text][vc_tta_accordion c_position=&#8221;right&#8221; active_section=&#8221;0&#8243; collapsible_all=&#8221;true&#8221; el_class=&#8221;accordion-isn&#8221;][vc_tta_section title=&#8221;Pathophysiology of the Glomerulus&#8221; tab_id=&#8221;milestones-january&#8221;][vc_column_text]To celebrate ISN\u2019s 60th anniversary throughout 2020, <em>Kidney International<\/em>\u2019s \u201cMilestones in Nephrology\u201d series launches with\u00a0<a href=\"https:\/\/www.kidney-international.org\/action\/showFullTextImages?pii=S0085-2538%2819%2931141-X\" target=\"_blank\" rel=\"noopener noreferrer\">a review of the development in understanding of the pathophysiology of the glomerulus<\/a>, highlighting several original articles published in <em>KI<\/em>:<\/p>\n<ul class=\"list list-icons list-icons-sm\">\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>The glomerular signature in patients with hematuria<\/strong> (Kenneth F. Fairley and Douglas F. Birch, 1982);<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>The permselectivity of the glomerular capillary wall\u00a0<\/strong>(Ramsay L.S. Chang, William M. Deen, Channing R. Robertson, and Barry M. Brenner, 1975);<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>T-cells and macrophages in rapidly progressive glomerulonephritis: clinicopathologic correlations<\/strong>\u00a0(Bolton W.K., Innes D.J. Jr., Sturgill B.C., Kaiser D.L., 1987);<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Glomerular hemodynamic changes vs. hypertrophy in experimental glomerular sclerosis<\/strong>(Yoshida Y., Fogo A., Ichikawa I., 1989); and<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Genetic studies into inherited and sporadic hemolytic uremic syndrome<\/strong>(Warwicker P., Goodship T.H.J., Donne R.L., et al., 1998).<\/li>\n<\/ul>\n<p>These articles, despite sometimes triggering controversy, opened the way for improved patient care, innovative therapeutic intervention, and genetic screening.<\/p>\n<p>These groundbreaking papers from <em>KI<\/em>, shared monthly, will be discussed by an editor from <em>KI<\/em> and put into perspective of the most recent advances in the field.[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Treasure Hunt for the Kidney Tubule&#8221; tab_id=&#8221;milestones-february&#8221;][vc_column_text]To celebrate ISN\u2019s 60th anniversary,\u00a0<em>Kidney International\u2019s\u00a0<\/em>\u201c<a href=\"https:\/\/www.kidney-international.org\/article\/S0085-2538(20)30239-8\/abstract\" target=\"_blank\" rel=\"noopener noreferrer\">Milestones in Nephrology<\/a>\u201d series continues with\u00a0a review of five foundational contributions related to various tubular segments in the normal and diseased kidney:<\/p>\n<ul class=\"list list-icons list-icons-sm\">\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Model for bicarbonate and fluid reabsorption in the proximal tubule<\/strong>\u00a0(McKinney TD, Burg MB., 1977)<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Intralysosomal digestion of endocytosed proteins in proximal tubule cells\u00a0<\/strong>(Christensen EI, Maunsbach AB., 1974)<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>The countercurrent multiplication system in the medulla<\/strong>\u00a0(Kokko JP, Rector FC Jr., 1972)<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Treatment of Bartter syndrome with indomethacin<\/strong>\u00a0(Verberckmoes R, van Damme BB, Clement J, et al., 1976)<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Plasticity in the distal nephron following acid-base modifications<\/strong>\u00a0(Hag\u00e9ge J, Gabe M, Richet G., 1974)<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Treatment of Glomerular Diseases: Pioneering Clinical Trials&#8221; tab_id=&#8221;milestones-march&#8221;][vc_column_text]Celebrating ISN\u2019s 60th anniversary, <a href=\"https:\/\/www.kidney-international.org\/\" target=\"_blank\" rel=\"noopener noreferrer\"><em>Kidney International\u2019s<\/em><\/a> &#8220;Milestones in Nephrology&#8221; series continues with a review of some of the original articles it has published on the treatment of glomerular disease, publications that helped make significant changes in patient management:<\/p>\n<ul class=\"list list-icons list-icons-sm\">\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Shorter term corticosteroids are equally effective as longer term in primary nephrotic syndrome in children<\/strong>\u00a0(Yoshikawa N, Nakanishi K, Sako M, et\u00a0al.)<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Calcineurin inhibitors in focal segmental glomerulosclerosis and membranous nephropathy<\/strong>\u00a0(Cattran DC, Appel GB, Hebert LA, et\u00a0al.)<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>High-dose melphalan and autologous stem cell transplantation is feasible in end-stage kidney failure patients with amyloid light-chain (AL)<\/strong>\u00a0amyloidosis (Casserly LF, Fadia A, Sanchorawala V, et al.)<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Renal effects of enzyme replacement therapy in Fabry disease (FD<\/strong>) (Thurberg BL, Rennke H, Colvin RB, et al.)<\/li>\n<\/ul>\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.kint.2019.12.011\" target=\"_blank\" rel=\"noopener noreferrer\">Read more<\/a>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Morphology Expands Understanding of Lesions&#8221; tab_id=&#8221;milestones-april&#8221;][vc_column_text]To celebrate ISNs 60th anniversary, Kidney International\u2019s \u201c<a href=\"https:\/\/www.kidney-international.org\/content\/milesstones\" target=\"_blank\" rel=\"noopener noreferrer\">Milestones in Nephrology<\/a>\u201d series continues with\u00a0<a href=\"https:\/\/www.kidney-international.org\/article\/S0085-2538(20)30097-1\/fulltext\" target=\"_blank\" rel=\"noopener noreferrer\">Agnes B. Fogo\u2019s review of some of the original articles KI has published on renal morphology<\/a>:<\/p>\n<ul class=\"list list-icons list-icons-sm\">\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Nephrin\u2019s role in the podocyte<\/strong>\u00a0(Holzman LB, St. John PL, Kovari IA, et al., 1999);<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Plasticity of podocytes<\/strong>\u00a0(Bari\u00e9ty J, Nochy D, Mandet C, et al.,1998);<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Podocyte loss linked to glomerulosclerosis<\/strong>\u00a0(Kim YH, Goyal M, Kurnit D, et al.,2001);<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Novel entity linked to monoclonal protein deposition<\/strong>\u00a0(Nasr SH, Markowitz GS, Stokes MB, et al., 2004); and<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>IgA nephropathy morphologic risk factors defined<\/strong>\u00a0(Roberts ISD, Cook HT, Troyanov S, et al., 2009; Cattran DC, Coppo R, Cook HT, et al., 2009).<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Treasure Hunt for the Kidney Tubule&#8221; tab_id=&#8221;milestones-may&#8221;][vc_column_text]To celebrate ISN\u2019s 60th anniversary,\u00a0<em>Kidney International\u2019s\u00a0<\/em>\u201c<a href=\"https:\/\/www.kidney-international.org\/article\/S0085-2538(20)30239-8\/abstract\" target=\"_blank\" rel=\"noopener noreferrer\">Milestones in Nephrology<\/a>\u201d series continues with\u00a0a review of five foundational contributions related to various tubular segments in the normal and diseased kidney:<\/p>\n<ul class=\"list list-icons list-icons-sm\">\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Model for bicarbonate and fluid reabsorption in the proximal tubule<\/strong>\u00a0(McKinney TD, Burg MB., 1977)<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Intralysosomal digestion of endocytosed proteins in proximal tubule cells\u00a0<\/strong>(Christensen EI, Maunsbach AB., 1974)<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>The countercurrent multiplication system in the medulla<\/strong>\u00a0(Kokko JP, Rector FC Jr., 1972)<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Treatment of Bartter syndrome with indomethacin<\/strong>\u00a0(Verberckmoes R, van Damme BB, Clement J, et al., 1976)<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Plasticity in the distal nephron following acid-base modifications<\/strong>\u00a0(Hag\u00e9ge J, Gabe M, Richet G., 1974)<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Kidney Stones&#8221; tab_id=&#8221;milestones-june&#8221;][vc_column_text]As part of ISN\u2019s 60th-anniversary, Kidney International\u2019s \u201c<a href=\"https:\/\/www.kidney-international.org\/article\/S0085-2538(20)30239-8\/abstract\" target=\"_blank\" rel=\"noopener noreferrer\">Milestones in Nephrology<\/a>\u201d series highlights five key contributions to the multidisciplinary field of kidney stone disease:<\/p>\n<ul class=\"list list-icons list-icons-sm\">\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Estimating the burden of kidney stone disease<\/strong>\u00a0(Johnson CM, Wilson DM, O\u2019Fallon WM, et al., 1979)<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Urine chemistry as a window into kidney stone risk<\/strong>\u00a0(Curhan GC, Willett WC, Speizer FE, Stampfer MJ., 2001)<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Identifying risk factors for hyperoxaluria and calcium oxalate stones<\/strong>\u00a0(Holmes RP, Goodman HO, Assimos DG., 2007)<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Linking the metabolic syndrome to kidney stone risk: epidemiology and mechanisms<\/strong>\u00a0(Abate N, Chandalia M, Cabo-Chan AV Jr., et al. 2005)<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Beyond stones: implicating hyperuricemia in hypertension and kidney disease<\/strong>\u00a0(Sanchez-Lozada LG, Tapia E, Santamaria J, et al., 2005)<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Dialysis Computation, Experimentation, and Implementation&#8221; tab_id=&#8221;milestones-july&#8221;][vc_column_text]As part of ISN\u2019s 60<sup>th<\/sup>-anniversary,\u00a0<em>Kidney International\u2019s\u00a0<\/em>\u201c<a href=\"https:\/\/www.kidney-international.org\/article\/S0085-2538(20)30662-1\/fulltext?dgcid=raven_jbs_etoc_email\" target=\"_blank\" rel=\"noopener noreferrer\">Milestones in Nephrology<\/a>\u201d series highlights five significant contributions to the understanding of hemodialysis and peritoneal dialysis:<\/p>\n<ul class=\"list list-icons list-icons-sm\">\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>A mechanistic analysis of the National Cooperative Dialysis Study (NCDS)\u00a0<\/strong>(Gotch FA, Sargent JA, 1985)<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Computer simulations of peritoneal fluid transport in CAPD<\/strong>\u00a0(Rippe B, Stelin G, Haraldsson B, 1991)<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Nitrogen balance during intermittent dialysis therapy of uremia<\/strong>\u00a0(Borah MF, Schoenfeld PY, Gotch FA, et\u00a0al., 1978)<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Biocompatibility of dialysis membranes: effects of chronic complement activation<\/strong>\u00a0(Hakim RM, Fearon DT, Lazarus JM, 1984)<\/li>\n<li><i class=\"fa fa-caret-right\"><\/i> <strong>Outcome of patients with human immunodeficiency virus on maintenance hemodialysis<\/strong>\u00a0(Ortiz C, Meneses R, Jaffe D, et\u00a0al., 1988)<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Dialysis: learning dialysis through computation, experimentation, and implementation&#8221; tab_id=&#8221;milestones-august&#8221;][vc_column_text]<span class=\"TextRun Highlight SCXW35509272 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW35509272 BCX0\">As part of ISN\u2019s 60<\/span><\/span><span class=\"TextRun Highlight SCXW35509272 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun Superscript SCXW35509272 BCX0\" data-fontsize=\"14\">th<\/span><\/span><span class=\"TextRun Highlight SCXW35509272 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW35509272 BCX0\">-anniversary,\u00a0<\/span><\/span><span class=\"TextRun Highlight SCXW35509272 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW35509272 BCX0\">Kidney International\u2019s\u00a0<\/span><\/span><span class=\"TextRun Highlight SCXW35509272 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW35509272 BCX0\">\u201c<\/span><\/span><a class=\"Hyperlink SCXW35509272 BCX0\" href=\"https:\/\/www.kidney-international.org\/article\/S0085-2538(20)30503-2\/fulltext?dgcid=raven_jbs_etoc_email\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"TextRun Highlight Underlined SCXW35509272 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW35509272 BCX0\" data-ccp-charstyle=\"Hyperlink\">Milestones in Nephrolo<\/span><\/span><span class=\"TextRun Highlight Underlined SCXW35509272 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW35509272 BCX0\" data-ccp-charstyle=\"Hyperlink\">g<\/span><\/span><span class=\"TextRun Highlight Underlined SCXW35509272 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW35509272 BCX0\" data-ccp-charstyle=\"Hyperlink\">y<\/span><\/span><\/a><span class=\"TextRun Highlight SCXW35509272 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW35509272 BCX0\">\u201d series highlights five\u00a0<\/span><\/span><span class=\"TextRun Highlight SCXW35509272 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW35509272 BCX0\">significant\u00a0<\/span><\/span><span class=\"TextRun Highlight SCXW35509272 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW35509272 BCX0\">contributions\u00a0<\/span><\/span><span class=\"TextRun Highlight SCXW35509272 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW35509272 BCX0\">to<\/span><\/span><span class=\"TextRun Highlight SCXW35509272 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW35509272 BCX0\">acute kidney injury, diabetic kidney disease, and cell biology<\/span><\/span><span class=\"TextRun Highlight SCXW35509272 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW35509272 BCX0\">:<\/span><\/span><\/p>\n<ul>\n<li><strong><span data-contrast=\"auto\">Glomerular hemodynamics in experimental diabetes mellitus<\/span><\/strong><span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">Hostetter TH, Troy JL, Brenner BM<\/span><span data-contrast=\"auto\">, 1981<\/span><span data-contrast=\"auto\">)<\/span><\/li>\n<li><strong><span data-contrast=\"auto\">Effect of intensive therapy on the development and progression of diabetic nephropathy in the Diabetes Control and Complications Trial<\/span><\/strong><strong><span data-contrast=\"auto\">\u202f<\/span><\/strong><span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">The Diabetes Control and Complicatio<\/span><span data-contrast=\"auto\">ns Trial (DCCT) Research Group, 1995)<\/span><\/li>\n<li><span data-contrast=\"auto\">Kidney injury molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule\u00a0<\/span><span data-contrast=\"auto\">injury<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-contrast=\"auto\">(Han WK, Bailly V,\u00a0Abichandani\u00a0R, et\u202fal. 2002)<\/span><\/li>\n<li><span data-contrast=\"auto\">\u202fHK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidney<\/span><span data-contrast=\"auto\">(Ryan MJ, Johnson G, Kirk J, et\u202fal. 1994)<\/span><\/li>\n<li><span data-contrast=\"auto\">Identification of the renal erythropoietin-producing cells using transgenic mice<\/span><span data-contrast=\"none\">\u202f<\/span><span data-contrast=\"none\">(<\/span><span data-contrast=\"none\">Maxwell PH, Osmond MK, Pugh CW, et\u202fal<\/span><span data-contrast=\"none\">. 1993)<\/span><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Cardiovascular complications of chronic kidney disease: pioneering studies&#8221; tab_id=&#8221;milestones-sept&#8221;][vc_column_text]As part of ISN\u2019s 60<sup>th<\/sup>-anniversary, <em>Kidney International\u2019s <\/em>\u201c<a href=\"https:\/\/bit.ly\/2H24aqx\" target=\"_blank\" rel=\"noopener noreferrer\">Milestones in Nephrology<\/a>\u201d series highlights five significant contributions to cardiovascular disease in patients with chronic kidney disease:<\/p>\n<p><strong>Ischemic heart disease in patients on hemodialysis therapy<\/strong> (Rostand SG, Gretes JC, Kirk KA, et al., 1979)<\/p>\n<p><strong>Uremia-associated increase in myocardial interstitial fibrosis<\/strong> (Mall G, Rambausek M, Neumeister A, et al., 1988)<\/p>\n<p><strong>Aortic pulse wave velocity index and mortality in end-stage renal disease<\/strong> (Blacher J, Safar ME, Guerin AP, et al., 2003)<\/p>\n<p><strong>Effect of anemia correction on established LVH in patients undergoing hemodialysis therapy<\/strong> (Foley RN, Parfrey PS, Morgan J, et al., 2000)<\/p>\n<p><strong>Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients<\/strong> (Chertow GM, Burke SK, Raggi P, et al., 2002)[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Mineral and Bone Disorders in Chronic Kidney Disease: Pioneering Studies&#8221; tab_id=&#8221;milestones-oct&#8221;][vc_column_text]As part of ISN\u2019s 60th-anniversary, Kidney International\u2019s \u201c<a href=\"https:\/\/www.kidney-international.org\/article\/S0085-2538(20)30816-4\/fulltext\" target=\"_blank\" rel=\"noopener noreferrer\">Milestones in Nephrology<\/a>\u201d series highlights five papers dealing with bone and mineral disorders in chronic kidney disease:<\/p>\n<p><strong>Bone histology changes in CKD<\/strong> (Malluche HH, Ritz E, Lange HP, et\u202fal., 1976)<\/p>\n<p><strong>Prevention of secondary hyperparathyroidism in CKD by reducing phosphorus intake<\/strong> (Slatopolsky E, Caglar S, Gradowska L, et\u202fal., 1972)<\/p>\n<p><strong>Depressed calcium-sensing receptor expression in hyperparathyroidism<\/strong> (Gogusev J, Duchambon P, Hory B, et\u202fal., 1997)<\/p>\n<p><strong>Abnormal calcium homeostasis in adynamic bone disease<\/strong> (Kurz P, Monier-Faugere M-C, Bognar B, et\u202fal.. 1994)<\/p>\n<p><strong>Dialysis-associated amyloidosis and periarticular bone resorption<\/strong> (Gejyo F, Odani S, Yamada T, et\u202fal., 1986)[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Transplantation \u2013 the Chosen 5&#8243; tab_id=&#8221;milestones-nov&#8221;][vc_column_text]As the ISN\u2019s flagship journal that established itself in a golden age of physiology and pathology, Kidney International published diverse seminal papers on kidney transplantation.<\/p>\n<p>As part of ISN\u2019s 60th-anniversary, Kidney International\u2019s \u201c<a href=\"https:\/\/www.kidney-international.org\/article\/S0085-2538(20)31080-2\/fulltext\" target=\"_blank\" rel=\"noopener noreferrer\">Milestones in Nephrology<\/a>\u201d series presents five papers selected by Germaine Wong, ISN Clinical Research Team member, and Toby Coates, Associate Editor KI Editorial Board, that made significant contributions in the field of kidney transplantation:<\/p>\n<p><strong>Recurrence of mesangial deposition of IgA after renal transplantation<\/strong><\/p>\n<p>(Berger J, Yaneva H, Nabarra B, Barbanel C., 1975)<\/p>\n<p><strong>A study of quality of life and cost-utility of renal transplantation<\/strong><\/p>\n<p>(Laupacis A, Kweon P, Pus N, et\u202fal., 1960)<\/p>\n<p><strong>Capillary deposition of C4d complement fragment and early renal graft loss<\/strong><\/p>\n<p>(Feucht HE, Schneeberger H, Hillebrand G, et\u202fal., 1993)<\/p>\n<p><strong>Long-term survival in renal transplant recipients with graft function<\/strong><\/p>\n<p>(Ojo AO, Hanson JA, Wolfe RA, et\u202fal., 2000)<\/p>\n<p><strong>Long-term risks for kidney donors<\/strong><\/p>\n<p>Mj\u00f8en G, Hallan S, Hartmann A, et\u202fal., 2014)[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Epidemiology of kidney disease &#8211; consolidating and integrating the evidence to improve kidney care from early childhood to adulthood&#8221; tab_id=&#8221;milestones-dec&#8221;][vc_column_text]The last article in Kidney International\u2019s \u201cMilestones in Nephrology\u201d series, to mark ISN\u2019s 60th-anniversary, presents five papers selected that made significant contributions in the clinical epidemiology of kidney disease, from childhood to adulthood:<\/p>\n<p><strong>Relationship between weight at birth and the number and size of renal glomeruli in humans: A histomorphometric study<\/strong><\/p>\n<p>(Ma\u00f1alich R, Reyes L, Herrera M, Melendi C, Fundora I, 2000)<\/p>\n<p><strong>Epidemiology of acute renal failure: A prospective, multicenter, community-based study<\/strong><\/p>\n<p>Lia\u00f1o F, Pascual J, The Madrid Acute Renal Failure Study Group, 1996)<\/p>\n<p><strong>Plasma lipids and risk of developing renal dysfunction: The Atherosclerosis Risk in Communities (ARIC) study<\/strong><\/p>\n<p>(Muntner P, Coresh J, Smith JC, et al., 2000)<\/p>\n<p><strong>Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure<\/strong><\/p>\n<p>(Stenvinkel P, Heimb\u00fcrger O, Paultre F, et al., 1999)<\/p>\n<p><strong>Biomarkers for the diagnosis and risk stratification of acute kidney injury: A systematic review<\/strong><\/p>\n<p>(Coca SG, Yalavarthy R, Concato J, Parikh CR., 2008)[\/vc_column_text][\/vc_tta_section][\/vc_tta_accordion][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text]To mark ISN&#8217;s 60th anniversary, a monthly series, \u201cMilestones in Nephrology,\u201d\u00a0was developed by the editorial team at Kidney International\u00a0(KI). The series highlights 60 historical papers of importance to the nephrology community from the early days of KI. Groundbreaking KI papers are discussed by an editor in light of more recent advances in the field. &nbsp; [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":2454,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-4298","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.theisn.org\/wp-json\/wp\/v2\/pages\/4298"}],"collection":[{"href":"https:\/\/www.theisn.org\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.theisn.org\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.theisn.org\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.theisn.org\/wp-json\/wp\/v2\/comments?post=4298"}],"version-history":[{"count":7,"href":"https:\/\/www.theisn.org\/wp-json\/wp\/v2\/pages\/4298\/revisions"}],"predecessor-version":[{"id":12469,"href":"https:\/\/www.theisn.org\/wp-json\/wp\/v2\/pages\/4298\/revisions\/12469"}],"up":[{"embeddable":true,"href":"https:\/\/www.theisn.org\/wp-json\/wp\/v2\/pages\/2454"}],"wp:attachment":[{"href":"https:\/\/www.theisn.org\/wp-json\/wp\/v2\/media?parent=4298"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}