SPK (simultaneous pancreas-kidney transplant) is an established\u00a0<\/span>option<\/span>\u00a0for selected patients with T1DM and ESKD. We report a 34-year-old woman with long-standing T1DM, hypertension,\u00a0<\/span>dyslipidaemia<\/span>\u00a0and hypothyroidism, complicated by diabetic nephropathy progressing to ESKD, on twice-weekly\u00a0<\/span>haemodialysis<\/span>\u00a0for 2 years.\u00a0<\/span>Glycaemic<\/span>\u00a0and blood pressure control remained poor despite maximal medical therapy. She was evaluated for kidney transplantation with consideration of SPK due to insulin dependence and metabolic instability. Multidisciplinary assessment guided transplant strategy in this high-risk young patient.<\/span><\/span><\/p>\n This case illustrates the complex decision-making involved in transplant planning for young patients with long-standing type 1 diabetes mellitus complicated by end-stage kidney disease and multiple metabolic comorbidities. It highlights the clinical importance of considering simultaneous pancreas-kidney transplantation (SPK) in selected patients with insulin-dependent diabetes and poor\u00a0<\/span>glycaemic<\/span>\u00a0control despite\u00a0<\/span>optimal<\/span>\u00a0medical therapy. The case underscores the need for early referral and comprehensive multidisciplinary assessment to balance perioperative risk against long-term metabolic and renal benefits. Careful patient selection\u00a0<\/span>remains<\/span>\u00a0critical to\u00a0<\/span>optimizing<\/span>\u00a0outcomes and improving quality of life in this high-risk population.<\/span><\/span>\u00a0<\/span><\/p>\n<\/div>\n To highlight the clinical profile and transplant eligibility assessment of a young patient with type 1 diabetes mellitus complicated by end-stage kidney disease and multiple metabolic comorbidities.<\/span><\/p>\n<\/li>\n To discuss the role of SPK (simultaneous pancreas-kidney transplant) in achieving combined renal replacement and metabolic control in patients with insulin-dependent diabetes and dialysis dependence.<\/p>\n<\/li>\n To review current guideline-based indications, patient selection criteria, and contraindications for SPK in the context of complex cardiovascular and endocrine comorbidities.<\/span><\/p>\n<\/li>\n To emphasize the importance of multidisciplinary evaluation inoptimizing\u00a0transplant outcomes and individualized decision-making between kidney-alone transplantation and SPK.<\/span>\u00a0<\/span><\/p>\n<\/li>\n<\/ul>\n [\/vc_column_text][vc_row_inner equal_height=”yes”][vc_column_inner width=”1\/2″][vc_column_text css=”.vc_custom_1777286945200{margin-top: 10px !important;margin-right: 10px !important;margin-bottom: 10px !important;margin-left: 10px !important;padding-top: 20px !important;padding-right: 20px !important;padding-bottom: 20px !important;padding-left: 20px !important;background-color: #ebebeb !important;border-radius: 5px !important;}” el_class=”spk”]<\/p>\n Moderator<\/strong><\/p>\n Robert Freercks (South Africa)<\/span><\/p>\n [\/vc_column_text][\/vc_column_inner][vc_column_inner width=”1\/2″][vc_column_text css=”.vc_custom_1779367739019{margin-top: 10px !important;margin-right: 10px !important;margin-bottom: 10px !important;margin-left: 10px !important;padding-top: 20px !important;padding-right: 20px !important;padding-bottom: 20px !important;padding-left: 20px !important;background-color: #ebebeb !important;border-radius: 5px !important;}” el_class=”spk”]<\/p>\n Speakers<\/strong><\/p>\n Chanaka Aberathna (Sri Lanka)<\/p>\n Niroshan Seneviratne (Sri Lanka)<\/p>\n Pedro Ventura (Spain)<\/p>\n \u00a0[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row content_placement=”middle” css=”.vc_custom_1671727669697{margin-bottom: 25px !important;}”][vc_column width=”1\/6″][\/vc_column][vc_column width=”2\/3″ css=”.vc_custom_1671441207906{border-top-width: 2px !important;border-right-width: 2px !important;border-bottom-width: 2px !important;border-left-width: 2px !important;background-color: #2c317a !important;border-left-color: #dd9933 !important;border-left-style: dotted !important;border-right-color: #dd9933 !important;border-right-style: dotted !important;border-top-color: #dd9933 !important;border-top-style: dotted !important;border-bottom-color: #dd9933 !important;border-bottom-style: dotted !important;border-radius: 3px !important;}”][vc_column_text el_class=”banner-color” css=”.vc_custom_1746461741282{margin-bottom: 0px !important;}”]Access the previous ISN-TTS Grand Rounds on the ISN Academy<\/p>\n [\/vc_column_text][vc_btn title=”Click here” shape=”round” color=”pink” align=”right” link=”url:https%3A%2F%2Facademy.theisn.org%2Fproducts%2Fgrand-round-in-transplant-nephrology||target:%20_blank|”][\/vc_column][vc_column width=”1\/6″][\/vc_column][\/vc_row][vc_row disable_element=”yes”][vc_column][vc_column_text]\n\t\t\t <\/p>\n\t\t\t<\/h4>\n
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